Pharmacological inhibition of platelet-tumor cell cross-talk prevents platelet-induced overexpression of cyclooxygenase-2 in HT29 human colon carcinoma cells.

Dovizio, Melania; Maier, Thorsten J; Alberti, Sara; Di Francesco, Luigia; Marcantoni, Emanuela; Münch, Götz; John, Constance M; Suess, Beatrix; Sgambato, Alessandro; Steinhilber, Dieter; Patrignani, Paola

Dovizio, Melania; Maier, Thorsten J; Alberti, Sara; Di Francesco, Luigia; Marcantoni, Emanuela; Münch, Götz; John, Constance M; Suess, Beatrix; Sgambato, Alessandro; Steinhilber, Dieter; Patrignani, Paola.

Affiliation

Dovizio M; Department of Neuroscience and Imaging and Center of Excellence on Aging (CeSI), G. d'Annunzio University, Via dei Vestini, 31, 66100 Chieti, Italy.

Mol Pharmacol ; 84(1): 25-40, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23580446

Subject(s)

Blood Platelets/drug effects; Blood Platelets/pathology; Cell Communication/drug effects; Colonic Neoplasms/blood; Colonic Neoplasms/enzymology; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Binding Sites; Blood Platelets/enzymology; Blood Platelets/metabolism; Cell Communication/genetics; Cell Line, Tumor; Colonic Neoplasms/genetics; Colonic Neoplasms/metabolism; Cyclin B1/genetics; Cyclin B1/metabolism; Cyclooxygenase 2 Inhibitors/pharmacology; Dinoprostone/genetics; Dinoprostone/metabolism; Down-Regulation/drug effects; Epithelial-Mesenchymal Transition/drug effects; Epithelial-Mesenchymal Transition/genetics; Galectin 3/antagonists & inhibitors; Galectin 3/genetics; Galectin 3/metabolism; Gene Expression/drug effects; Glycoproteins/pharmacology; HT29 Cells; Humans; Immunoglobulin Fc Fragments/pharmacology; Lactones/pharmacology; Lactose/pharmacology; Platelet-Derived Growth Factor/genetics; Platelet-Derived Growth Factor/metabolism; RNA, Messenger/genetics; Receptors, Collagen/genetics; Receptors, Collagen/metabolism; Sulfones/pharmacology; Up-Regulation/drug effects

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Platelets / Cell Communication / Colonic Neoplasms / Cyclooxygenase 2 Type of study: Prognostic_studies Language: En Journal: Mol Pharmacol Year: 2013 Document type: Article Affiliation country: Italy Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google