A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.

Esparza-Gordillo, Jorge; Schaarschmidt, Heidi; Liang, Liming; Cookson, William; Bauerfeind, Anja; Lee-Kirsch, Min-Ae; Nemat, Katja; Henderson, John; Paternoster, Lavinia; Harper, John I; Mangold, Elisabeth; Nothen, Markus M; Rüschendorf, Franz; Kerscher, Tamara; Marenholz, Ingo; Matanovic, Anja; Lau, Susanne; Keil, Thomas; Bauer, Carl-Peter; Kurek, Michael; Ciechanowicz, Andrzej; Macek, Milan; Franke, Andre; Kabesch, Michael; Hubner, Norbert; Abecasis, Gonçalo; Weidinger, Stephan; Moffatt, Miriam; Lee, Young-Ae

Esparza-Gordillo, Jorge; Schaarschmidt, Heidi; Liang, Liming; Cookson, William; Bauerfeind, Anja; Lee-Kirsch, Min-Ae; Nemat, Katja; Henderson, John; Paternoster, Lavinia; Harper, John I; Mangold, Elisabeth; Nothen, Markus M; Rüschendorf, Franz; Kerscher, Tamara; Marenholz, Ingo; Matanovic, Anja; Lau, Susanne; Keil, Thomas; Bauer, Carl-Peter; Kurek, Michael; Ciechanowicz, Andrzej; Macek, Milan; Franke, Andre; Kabesch, Michael; Hubner, Norbert; Abecasis, Gonçalo; Weidinger, Stephan; Moffatt, Miriam; Lee, Young-Ae.

Affiliation

Esparza-Gordillo J; Pediatric Allergology, Experimental and Clinical Research Center, Charité Universitätsmedizin Berlin, Berlin, Germany.

J Allergy Clin Immunol ; 132(2): 371-7, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23582566

Subject(s)

Dermatitis, Atopic/genetics; Genetic Predisposition to Disease; Polymorphism, Single Nucleotide; Receptors, Interleukin-6/genetics; Adolescent; Alleles; Child; Child, Preschool; Cohort Studies; Female; Genome-Wide Association Study; Genotype; Humans; Infant; Infant, Newborn; Interleukin-6/genetics; Interleukin-6/metabolism; Male; Receptors, Interleukin-6/blood; Risk Factors

Key words

AD; ALSPAC; Atopic dermatitis; Avon Longitudinal Study of Parents and Children; GWAS; Genome-wide association study; IL-6 receptor; IL-6R; MAS; Multicenter Allergy Study; OR; Odds ratio; SNP; Single nucleotide polymorphism; candidate association study; genetic risk factor; inflammation; longitudinal study; persistent atopic dermatitis; population-based cohort; prognosis; single nucleotide polymorphism; soluble IL-6 receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Interleukin-6 / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Dermatitis, Atopic Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Language: En Journal: J Allergy Clin Immunol Year: 2013 Document type: Article Affiliation country: Germany Country of publication: United States

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