Crystal structure of arginase from Leishmania mexicana and implications for the inhibition of polyamine biosynthesis in parasitic infections.

D'Antonio, Edward L; Ullman, Buddy; Roberts, Sigrid C; Dixit, Upasna Gaur; Wilson, Mary E; Hai, Yang; Christianson, David W

D'Antonio, Edward L; Ullman, Buddy; Roberts, Sigrid C; Dixit, Upasna Gaur; Wilson, Mary E; Hai, Yang; Christianson, David W.

Affiliation

D'Antonio EL; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104-6323, USA.

Arch Biochem Biophys ; 535(2): 163-76, 2013 Jul 15.

Article in En | MEDLINE | ID: mdl-23583962

Subject(s)

Arginase/chemistry; Leishmania mexicana/enzymology; Protozoan Proteins/chemistry; Aminocaproates/chemistry; Aminocaproates/pharmacology; Animals; Antiparasitic Agents/pharmacology; Arginase/antagonists & inhibitors; Arginine/analogs & derivatives; Arginine/chemistry; Arginine/pharmacology; Boron Compounds/chemistry; Boron Compounds/pharmacology; Crystallography, X-Ray; Female; Humans; Leishmania mexicana/drug effects; Leishmaniasis, Cutaneous/enzymology; Leishmaniasis, Cutaneous/parasitology; Mice; Mice, Inbred BALB C; Models, Molecular; Ornithine/chemistry; Polyamines/antagonists & inhibitors; Polyamines/metabolism; Protein Conformation; Protein Multimerization; Protozoan Proteins/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginase / Leishmania mexicana / Protozoan Proteins Limits: Animals / Female / Humans Country/Region as subject: Mexico Language: En Journal: Arch Biochem Biophys Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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