A zebrafish model of CLN2 disease is deficient in tripeptidyl peptidase 1 and displays progressive neurodegeneration accompanied by a reduction in proliferation.

Mahmood, Fahad; Fu, Sonia; Cooke, Jennifer; Wilson, Stephen W; Cooper, Jonathan D; Russell, Claire

Mahmood, Fahad; Fu, Sonia; Cooke, Jennifer; Wilson, Stephen W; Cooper, Jonathan D; Russell, Claire.

Affiliation

Mahmood F; Department of Comparative Biomedical Sciences, Royal Veterinary College, Royal College Street, London, NW1 0TU, UK.

Brain ; 136(Pt 5): 1488-507, 2013 May.

Article in En | MEDLINE | ID: mdl-23587805

Subject(s)

Aminopeptidases/deficiency; Cell Proliferation; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/deficiency; Disease Progression; Neuronal Ceroid-Lipofuscinoses/enzymology; Neuronal Ceroid-Lipofuscinoses/pathology; Serine Proteases/deficiency; Aminopeptidases/genetics; Aminopeptidases/physiology; Animals; Animals, Genetically Modified; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/genetics; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/physiology; Disease Models, Animal; Growth Inhibitors/deficiency; Growth Inhibitors/genetics; Growth Inhibitors/physiology; Humans; Motor Activity/physiology; Neurodegenerative Diseases/enzymology; Neurodegenerative Diseases/genetics; Neurodegenerative Diseases/pathology; Neuronal Ceroid-Lipofuscinoses/genetics; Serine Proteases/genetics; Serine Proteases/physiology; Tripeptidyl-Peptidase 1; Zebrafish

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disease Progression / Cell Proliferation / Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Serine Proteases / Aminopeptidases / Neuronal Ceroid-Lipofuscinoses Limits: Animals / Humans Language: En Journal: Brain Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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