Darexaban: anticoagulant effects in mice and human plasma in vitro, antithrombotic effects in thrombosis and bleeding models in mice and effects of anti-inhibitor coagulant complex and recombinant factor VIIa.

Kaku, Seiji; Suzuki, Mami; Saitoh, Minori; Funatsu, Toshiyuki; Uemura, Toshio; Suzuki, Ken-ichi; Iwatsuki, Yoshiyuki; Kawasaki, Tomihisa

Kaku, Seiji; Suzuki, Mami; Saitoh, Minori; Funatsu, Toshiyuki; Uemura, Toshio; Suzuki, Ken-ichi; Iwatsuki, Yoshiyuki; Kawasaki, Tomihisa.

Affiliation

Kaku S; Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba-shi, Ibaraki 305-8585, Japan. seiji.kaku@jp.astellas.com

Thromb Res ; 131(5): 450-6, 2013 May.

Article in En | MEDLINE | ID: mdl-23591155

Subject(s)

Anticoagulants/pharmacology; Azepines/pharmacology; Benzamides/pharmacology; Hemorrhage/drug therapy; Thrombosis/drug therapy; Warfarin/therapeutic use; Animals; Anticoagulants/adverse effects; Azepines/adverse effects; Benzamides/adverse effects; Disease Models, Animal; Factor VIIa/pharmacology; Hemorrhage/blood; Humans; Male; Mice; Mice, Inbred ICR; Partial Thromboplastin Time; Prothrombin Time; Recombinant Proteins/pharmacology; Thrombosis/blood; Warfarin/adverse effects; Warfarin/pharmacology

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Thrombosis / Warfarin / Benzamides / Hemorrhage / Anticoagulants Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Thromb Res Year: 2013 Document type: Article Affiliation country: Japan

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google