Doxycycline restrains glia and confers neuroprotection in a 6-OHDA Parkinson model.

Lazzarini, Marcio; Martin, Sabine; Mitkovski, Miso; Vozari, Rita Raisman; Stühmer, Walter; Bel, Elaine Del

Lazzarini, Marcio; Martin, Sabine; Mitkovski, Miso; Vozari, Rita Raisman; Stühmer, Walter; Bel, Elaine Del.

Affiliation

Lazzarini M; Department of Morphology, Physiology and Pathology, School of Odontology of Ribeirão Preto (FORP), University of São Paulo (USP), Ribeirão Preto, SP, Brazil.

Glia ; 61(7): 1084-100, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23595698

Subject(s)

Doxycycline/therapeutic use; Neuroglia/drug effects; Neuroprotective Agents/therapeutic use; Parkinson Disease/drug therapy; Parkinson Disease/pathology; Adrenergic Agents/toxicity; Analysis of Variance; Animals; Brain/metabolism; Brain/pathology; Cyclooxygenase 2/metabolism; Disease Models, Animal; Glial Fibrillary Acidic Protein/metabolism; Macrophage-1 Antigen/metabolism; Male; Matrix Metalloproteinase 3/metabolism; Mice; Mice, Inbred C57BL; Motor Activity/drug effects; Oxidopamine/toxicity; Parkinson Disease/etiology; Parkinson Disease/physiopathology; Tyrosine 3-Monooxygenase/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Neuroglia / Doxycycline / Neuroprotective Agents Type of study: Etiology_studies Limits: Animals Language: En Journal: Glia Journal subject: NEUROLOGIA Year: 2013 Document type: Article Affiliation country: Brazil

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