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Mitochondrial genome depletion in human liver cells abolishes bile acid-induced apoptosis: role of the Akt/mTOR survival pathway and Bcl-2 family proteins.
Marin, Jose J G; Hernandez, Alicia; Revuelta, Isabel E; Gonzalez-Sanchez, Ester; Gonzalez-Buitrago, Jose M; Perez, Maria J.
Affiliation
  • Marin JJ; Laboratory of Experimental Hepatology and Drug Targeting, (HEVEFARM), IBSAL, CIBERehd; Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca, Spain, University of Salamanca, 37007 Salamanca, Spain.
  • Hernandez A; Laboratory of Experimental Hepatology and Drug Targeting, (HEVEFARM), IBSAL, CIBERehd.
  • Revuelta IE; Laboratory of Experimental Hepatology and Drug Targeting, (HEVEFARM), IBSAL, CIBERehd.
  • Gonzalez-Sanchez E; Laboratory of Experimental Hepatology and Drug Targeting, (HEVEFARM), IBSAL, CIBERehd; Department of Physiology and Pharmacology, University of Salamanca, 37007 Salamanca, Spain, University of Salamanca, 37007 Salamanca, Spain.
  • Gonzalez-Buitrago JM; University Hospital of Salamanca, IECSCYL-IBSAL, 37007 Salamanca, Spain; Department of Biochemistry and Molecular Biology, University of Salamanca, 37007 Salamanca, Spain.
  • Perez MJ; Laboratory of Experimental Hepatology and Drug Targeting, (HEVEFARM), IBSAL, CIBERehd; University Hospital of Salamanca, IECSCYL-IBSAL, 37007 Salamanca, Spain; Department of Biochemistry and Molecular Biology, University of Salamanca, 37007 Salamanca, Spain. Electronic address: mjperez@usal.es.
Free Radic Biol Med ; 61: 218-28, 2013 Aug.
Article in En | MEDLINE | ID: mdl-23597504
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Acids and Salts / Signal Transduction / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Proto-Oncogene Proteins c-akt / Genome, Mitochondrial / TOR Serine-Threonine Kinases Limits: Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2013 Document type: Article Affiliation country: Spain Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Acids and Salts / Signal Transduction / Apoptosis / Proto-Oncogene Proteins c-bcl-2 / Proto-Oncogene Proteins c-akt / Genome, Mitochondrial / TOR Serine-Threonine Kinases Limits: Humans Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2013 Document type: Article Affiliation country: Spain Country of publication: United States