Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse.

O'Connor, Richard M; Thakker, Deepak R; Schmutz, Markus; van der Putten, Herman; Hoyer, Daniel; Flor, Peter J; Cryan, John F

O'Connor, Richard M; Thakker, Deepak R; Schmutz, Markus; van der Putten, Herman; Hoyer, Daniel; Flor, Peter J; Cryan, John F.

Affiliation

O'Connor RM; Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland.

Neuropharmacology ; 72: 66-73, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23603202

Subject(s)

Anxiety/drug therapy; Anxiety/metabolism; RNA, Small Interfering/therapeutic use; Receptors, Metabotropic Glutamate/metabolism; Adaptation, Ocular/drug effects; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fear/drug effects; Hyperthermia, Induced/psychology; Male; Mice; Mice, Inbred BALB C; Motor Activity/drug effects; Pentylenetetrazole/toxicity; Receptors, Metabotropic Glutamate/genetics; Reflex, Startle/drug effects; Seizures/chemically induced; Seizures/drug therapy; Stress, Physiological/physiology; Swimming/psychology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anxiety / Receptors, Metabotropic Glutamate / RNA, Small Interfering Limits: Animals Language: En Journal: Neuropharmacology Year: 2013 Document type: Article Affiliation country: Ireland Country of publication: United kingdom

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