Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression.

Parker, Rex A; Garcia, Ricardo; Ryan, Carol S; Liu, Xiaoqin; Shipkova, Petia; Livanov, Valentin; Patel, Pritesh; Ho, Siew P

Parker, Rex A; Garcia, Ricardo; Ryan, Carol S; Liu, Xiaoqin; Shipkova, Petia; Livanov, Valentin; Patel, Pritesh; Ho, Siew P.

Affiliation

Parker RA; Cardiovascular Discovery Biology, Bristol-Myers Squibb Pharmaceutical Research and Development, Pennington, NJ 08534, USA. rex.parker@bms.com

J Lipid Res ; 54(9): 2400-9, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23614904

Subject(s)

Bile Acids and Salts/metabolism; Cholesterol/metabolism; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology; Proprotein Convertases/antagonists & inhibitors; Protease Inhibitors/pharmacology; Animals; Biological Transport/drug effects; Cholesterol/blood; Drug Interactions; Feces/chemistry; Female; Gene Expression Regulation/drug effects; Liver/drug effects; Liver/metabolism; Male; Mice; Mice, Inbred C57BL; Phenotype; Proprotein Convertase 9; Serine Endopeptidases

Key words

3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors; CYP7A1; N-ethyl N-nitrosourea mutagenesis; bile acid transporter; cholestasis; low desnsity lipoprotein receptor; proprotein convertase subtilisin-kexin-9 inhibitors; statins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Bile Acids and Salts / Cholesterol / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Proprotein Convertases Limits: Animals Language: En Journal: J Lipid Res Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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