&#945;-lipoic acid protects dopaminergic neurons against MPP+-induced apoptosis by attenuating reactive oxygen species formation.

Li, Da-Wei; Li, Guang-Ren; Lu, Yan; Liu, Zhi-Qiang; Chang, Ming; Yao, Ming; Cheng, Wei; Hu, Lin-Sen

α-lipoic acid protects dopaminergic neurons against MPP+-induced apoptosis by attenuating reactive oxygen species formation.

Li, Da-Wei; Li, Guang-Ren; Lu, Yan; Liu, Zhi-Qiang; Chang, Ming; Yao, Ming; Cheng, Wei; Hu, Lin-Sen.

Affiliation

Li DW; Department of Neurology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.

Int J Mol Med ; 32(1): 108-14, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23615851

Subject(s)

1-Methyl-4-phenylpyridinium/toxicity; Apoptosis/drug effects; Dopaminergic Neurons/drug effects; Dopaminergic Neurons/metabolism; Neuroprotective Agents/pharmacology; Reactive Oxygen Species/metabolism; Thioctic Acid/pharmacology; Animals; Caspase 3/metabolism; Cell Survival/drug effects; Membrane Potential, Mitochondrial/drug effects; PC12 Cells; Proto-Oncogene Proteins c-bcl-2/metabolism; Rats; bcl-2-Associated X Protein/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: 1-Methyl-4-phenylpyridinium / Thioctic Acid / Reactive Oxygen Species / Apoptosis / Neuroprotective Agents / Dopaminergic Neurons Limits: Animals Language: En Journal: Int J Mol Med Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2013 Document type: Article

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