Determination of the warfarin inhibition constant Ki for vitamin K 2,3-epoxide reductase complex subunit-1 (VKORC1) using an in vitro DTT-driven assay.

Bevans, Carville G; Krettler, Christoph; Reinhart, Christoph; Tran, Hélène; Koßmann, Katja; Watzka, Matthias; Oldenburg, Johannes

Bevans, Carville G; Krettler, Christoph; Reinhart, Christoph; Tran, Hélène; Koßmann, Katja; Watzka, Matthias; Oldenburg, Johannes.

Affiliation

Bevans CG; Department of Structural Biology, Max Planck Institute of Biophysics, Frankfurt-am-Main, Germany.

Biochim Biophys Acta ; 1830(8): 4202-10, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23618698

Subject(s)

Dithiothreitol/pharmacology; Mixed Function Oxygenases/antagonists & inhibitors; Warfarin/pharmacology; Humans; Kinetics; Vitamin K Epoxide Reductases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Warfarin / Dithiothreitol / Mixed Function Oxygenases Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2013 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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