Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.

Guo, Chuangxing; Linton, Angelica; Jalaie, Mehran; Kephart, Susan; Ornelas, Martha; Pairish, Mason; Greasley, Samantha; Richardson, Paul; Maegley, Karen; Hickey, Michael; Li, John; Wu, Xin; Ji, Xiaodong; Xie, Zhi

Guo, Chuangxing; Linton, Angelica; Jalaie, Mehran; Kephart, Susan; Ornelas, Martha; Pairish, Mason; Greasley, Samantha; Richardson, Paul; Maegley, Karen; Hickey, Michael; Li, John; Wu, Xin; Ji, Xiaodong; Xie, Zhi.

Affiliation

Guo C; Oncology Medicinal Chemistry, Pfizer Worldwide Research & Development, San Diego, CA 92121, USA.

Bioorg Med Chem Lett ; 23(11): 3358-63, 2013 Jun 01.

Article in En | MEDLINE | ID: mdl-23622982

Subject(s)

Benzimidazoles/chemistry; Carrier Proteins/agonists; Membrane Proteins/agonists; Pyrimidinones/chemistry; Thyroid Hormones/agonists; Binding Sites; Carrier Proteins/metabolism; Cell Line; Computer-Aided Design; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Humans; Kinetics; Membrane Proteins/metabolism; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Pyrimidinones/chemical synthesis; Pyrimidinones/metabolism; Structure-Activity Relationship; Thyroid Hormones/metabolism; Thyroid Hormone-Binding Proteins

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidinones / Thyroid Hormones / Benzimidazoles / Carrier Proteins / Membrane Proteins Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United kingdom

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