Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.

Gopishetty, Bhaskar; Zhang, Suhong; Kharkar, Prashant S; Antonio, Tamara; Reith, Maarten; Dutta, Aloke K

Gopishetty, Bhaskar; Zhang, Suhong; Kharkar, Prashant S; Antonio, Tamara; Reith, Maarten; Dutta, Aloke K.

Affiliation

Gopishetty B; Wayne State University, Department of Pharmaceutical Sciences, 259 Mack Ave, Detroit, MI 48202, USA.

Bioorg Med Chem ; 21(11): 3164-74, 2013 Jun 01.

Article in En | MEDLINE | ID: mdl-23623679

Subject(s)

Dopamine Agonists/chemical synthesis; Naphthalenes/chemical synthesis; Piperazines/chemical synthesis; Receptors, Dopamine D2/agonists; Receptors, Dopamine D3/agonists; Animals; CHO Cells; Cricetulus; Dopamine Agonists/chemistry; Guanosine 5'-O-(3-Thiotriphosphate)/chemistry; HEK293 Cells; Humans; Kinetics; Naphthalenes/chemistry; Piperazines/chemistry; Protein Binding; Radioligand Assay; Receptors, Dopamine D2/chemistry; Receptors, Dopamine D3/chemistry; Spiperone/chemistry; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Receptors, Dopamine D2 / Dopamine Agonists / Receptors, Dopamine D3 / Naphthalenes Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Document type: Article Affiliation country: United States

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