Successful treatment of acute hereditary angioedema attacks with self-administered icatibant in patients with venous access problems.
BMJ Case Rep
; 20132013 Apr 25.
Article
in En
| MEDLINE
| ID: mdl-23625675
ABSTRACT
Hereditary angioedema is a rare and potentially fatal autosomal dominant disorder characterised by unpredictable skin, gastrointestinal tract or respiratory tract oedema. Plasma-derived C1-esterase inhibitors are effective in the prophylaxis or treatment of hereditary angioedema type I and II attacks, but must be administered intravenously. This may be problematic in patients with venous access difficulties. Icatibant, a bradykinin B2-receptor antagonist, is administered subcutaneously. In July 2008 icatibant received approval for healthcare professional-administered treatment of hereditary angioedema attacks in adults. In 2011 it received European Medicines Agency and US Food and Drug Administration licences for patient-administered treatment of hereditary angioedema attacks. Given these approvals, and with the appropriate training, icatibant could provide the opportunity for patients to self-administer treatment. This is one of the first long-term follow-up reports of patients with hereditary angioedema using self-administered icatibant. During follow-up, icatibant remained effective and patient satisfaction was high.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bradykinin
/
Anti-Inflammatory Agents, Non-Steroidal
/
Angioedemas, Hereditary
Limits:
Adult
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
BMJ Case Rep
Year:
2013
Document type:
Article
Affiliation country:
Austria