Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle.

Lee, Hyo Min; Ok, Seong-Ho; Sung, Hui-Jin; Eun, So Young; Kim, Hye Jung; Lee, Soo Hee; Kang, Sebin; Shin, Il-Woo; Lee, Heon Keun; Chung, Young-Kyun; Choi, Mun-Jeoung; Bae, Sung Il; Sohn, Ju-Tae

Lee, Hyo Min; Ok, Seong-Ho; Sung, Hui-Jin; Eun, So Young; Kim, Hye Jung; Lee, Soo Hee; Kang, Sebin; Shin, Il-Woo; Lee, Heon Keun; Chung, Young-Kyun; Choi, Mun-Jeoung; Bae, Sung Il; Sohn, Ju-Tae.

Affiliation

Lee HM; Department of Anesthesiology and Pain Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Can J Physiol Pharmacol ; 91(4): 285-94, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23627840

Subject(s)

Aorta, Thoracic/drug effects; Arachidonate 5-Lipoxygenase/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Mepivacaine/pharmacology; Muscle Contraction/drug effects; Muscle, Smooth, Vascular/drug effects; Animals; Aorta, Thoracic/enzymology; Aorta, Thoracic/metabolism; Arachidonic Acid/metabolism; Cells, Cultured; Cyclooxygenase 2/metabolism; Endothelium, Vascular/drug effects; Endothelium, Vascular/enzymology; Endothelium, Vascular/metabolism; Enzyme Activation/drug effects; Male; Muscle, Smooth, Vascular/enzymology; Muscle, Smooth, Vascular/metabolism; Phosphorylation; Rats; Rats, Sprague-Dawley; Up-Regulation/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta, Thoracic / Arachidonate 5-Lipoxygenase / Extracellular Signal-Regulated MAP Kinases / Mepivacaine / Muscle Contraction / Muscle, Smooth, Vascular Limits: Animals Language: En Journal: Can J Physiol Pharmacol Year: 2013 Document type: Article

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