Mechanism of parathyroid hormone-mediated suppression of calcification markers in human intervertebral disc cells.

Madiraju, P; Gawri, R; Wang, H; Antoniou, J; Mwale, F

Madiraju, P; Gawri, R; Wang, H; Antoniou, J; Mwale, F.

Affiliation

Madiraju P; SMBD-Jewish General Hospital, Lady Davis Institute for Medical Research, Montreal, QC, Canada.

Eur Cell Mater ; 25: 268-83, 2013 May 02.

Article in En | MEDLINE | ID: mdl-23636951

Subject(s)

Calcification, Physiologic/drug effects; Intervertebral Disc/cytology; Intervertebral Disc/drug effects; Parathyroid Hormone/pharmacology; Adult; Aged; Alkaline Phosphatase/metabolism; Biomarkers/metabolism; Butadienes/pharmacology; Calcium/metabolism; Collagen Type II/genetics; Collagen Type II/metabolism; Collagen Type X/genetics; Collagen Type X/metabolism; Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors; Cyclic AMP-Dependent Protein Kinases/metabolism; Extracellular Space/drug effects; Extracellular Space/metabolism; Gene Expression Regulation/drug effects; Humans; Intervertebral Disc/enzymology; Isoquinolines/pharmacology; MAP Kinase Signaling System/drug effects; Middle Aged; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases/metabolism; Nitriles/pharmacology; Receptor, Parathyroid Hormone, Type 1/metabolism; SOX9 Transcription Factor/metabolism; Sulfonamides/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Parathyroid Hormone / Calcification, Physiologic / Intervertebral Disc Limits: Adult / Aged / Humans / Middle aged Language: En Journal: Eur Cell Mater Year: 2013 Document type: Article Affiliation country: Canada Country of publication: Switzerland

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