Integrated approach of in vivo and in vitro evaluation of the involvement of hepatic uptake organic anion transporters in the drug disposition in rats using rifampicin as an inhibitor.

Imaoka, Tomoki; Mikkaichi, Tsuyoshi; Abe, Koji; Hirouchi, Masakazu; Okudaira, Noriko; Izumi, Takashi

Imaoka, Tomoki; Mikkaichi, Tsuyoshi; Abe, Koji; Hirouchi, Masakazu; Okudaira, Noriko; Izumi, Takashi.

Affiliation

Imaoka T; Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. imaoka.tomoki.hd@daiichisankyo.co.jp

Drug Metab Dispos ; 41(7): 1442-9, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23640987

Subject(s)

Liver/metabolism; Organic Anion Transporters/physiology; Rifampin/pharmacology; Animals; Drug Interactions; Female; Hepatocytes/metabolism; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics; Metabolic Clearance Rate; Midazolam/pharmacokinetics; Organic Anion Transporters/antagonists & inhibitors; Rats; Rats, Sprague-Dawley; Sulfobromophthalein/pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / Organic Anion Transporters / Liver Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2013 Document type: Article Affiliation country: Japan

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