Size distribution of microbubbles as a function of shell composition.
Ultrasonics
; 53(7): 1363-7, 2013 Sep.
Article
in En
| MEDLINE
| ID: mdl-23642496
ABSTRACT
The effect of modifying the shell composition of a population of microbubbles on their size demonstrated through experiment. Specifically, these variations include altering both the mole fraction and molecular weight of functionalized polymer, polyethylene glycol (PEG) in the microbubble phospholipid monolayer shell (1-15 mol% PEG, and 1000-5000 g/mole, respectively). The size distribution is measured with an unbiased image segmentation program written in MATLAB which identifies and sizes bubbles from micrographs. For a population of microbubbles with a shell composition of 5 mol% PEG2000, the mean diameter is 1.42 µm with a variance of 0.244 µm. For the remainder of the shell compositions studied herein, we find that the size distributions do not show a statistically significant correlation to either PEG molecular weight or mole fraction. All the measured distributions are nearly Gaussian in shape and have a monomodal peak.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polyethylene Glycols
/
Ultrasonics
/
Contrast Media
/
Microbubbles
Limits:
Humans
Language:
En
Journal:
Ultrasonics
Year:
2013
Document type:
Article
Affiliation country:
United States