Hydrocephalus with hop gait (hyh): a new mutation on chromosome 7 in the mouse.
Brain Res Dev Brain Res
; 54(1): 131-6, 1990 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-2364541
ABSTRACT
Hydrocephalus with hop gait (hyh) is a new lethal recessive mouse mutation that arose in the C57BL/10J strain at The Jackson Laboratory. It has been mapped to the proximal end of Chromosome 7 close to the Gpi-1 locus. This homozygous mutant is characterized clinically by a domed head and a hopping gait observable at 2 weeks of age and death between 4 and 10 weeks of age. The affected mice have dilated lateral ventricles and a large third ventricular cyst, patent through narrowed rostral cerebral aqueduct, cystic caudal aqueduct and no communication of the aqueduct with the fourth ventricle. The cerebellum has a mild cortical malformation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hydrocephalus
/
Mice, Neurologic Mutants
/
Movement Disorders
Limits:
Animals
Language:
En
Journal:
Brain Res Dev Brain Res
Journal subject:
CEREBRO
/
NEUROLOGIA
Year:
1990
Document type:
Article