Optimized chemical probes for REV-ERB&#945;.

Trump, Ryan P; Bresciani, Stefano; Cooper, Anthony W J; Tellam, James P; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A; Kashatus, Jennifer A; Boudjelal, Mohamed; Dawson, Helen C; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N; Willson, Timothy M; Tomkinson, Nicholas C O

Optimized chemical probes for REV-ERBα.

Trump, Ryan P; Bresciani, Stefano; Cooper, Anthony W J; Tellam, James P; Wojno, Justyna; Blaikley, John; Orband-Miller, Lisa A; Kashatus, Jennifer A; Boudjelal, Mohamed; Dawson, Helen C; Loudon, Andrew; Ray, David; Grant, Daniel; Farrow, Stuart N; Willson, Timothy M; Tomkinson, Nicholas C O.

Affiliation

Trump RP; Molecular Discovery Research, GlaxoSmithKline, Research Triangle Park, North Carolina 27709-3398, USA. ryan.p.trump@gsk.com

J Med Chem ; 56(11): 4729-37, 2013 Jun 13.

Article in En | MEDLINE | ID: mdl-23656296

Subject(s)

Amines/chemical synthesis; Nuclear Receptor Subfamily 1, Group D, Member 1/agonists; Amines/chemistry; Amines/pharmacology; Animals; Biological Availability; Carrier Proteins/metabolism; Cell Line; Circadian Rhythm; Glycine/analogs & derivatives; Glycine/chemical synthesis; Glycine/chemistry; Glycine/pharmacology; Humans; Liver X Receptors; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors/metabolism; Peptide Fragments/metabolism; RNA-Binding Proteins; Radioligand Assay; Structure-Activity Relationship; Thiophenes/chemical synthesis; Thiophenes/chemistry; Thiophenes/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Receptor Subfamily 1, Group D, Member 1 / Amines Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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