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22q11.2 deletion syndrome with life-threatening adenovirus infection.
Ip, Winnie; Zhan, Hong; Gilmour, Kimberly C; Davies, E Graham; Qasim, Waseem.
Affiliation
  • Ip W; Molecular Immunology Unit, Institute of Child Health, University College London, London, United Kingdom. w.ip@ucl.ac.uk
J Pediatr ; 163(3): 908-10, 2013 Sep.
Article in En | MEDLINE | ID: mdl-23660376
ABSTRACT
Adenovirus causes significant morbidity and mortality in immunocompromised children. We report how an infusion of HLA-matched sibling donor T lymphocytes rapidly eradicated life-threatening, high-level adenoviremia in a child with complete DiGeorge syndrome (22q11.2 deletion) who went on to reconstitute a diverse, donor-derived, postthymic T-cell repertoire.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Adenovirus Infections, Human / Bone Marrow Transplantation / Immunocompromised Host / DiGeorge Syndrome Type of study: Diagnostic_studies Limits: Female / Humans / Infant Language: En Journal: J Pediatr Year: 2013 Document type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Adenovirus Infections, Human / Bone Marrow Transplantation / Immunocompromised Host / DiGeorge Syndrome Type of study: Diagnostic_studies Limits: Female / Humans / Infant Language: En Journal: J Pediatr Year: 2013 Document type: Article Affiliation country: United kingdom