Using one-step nucleic acid amplification (OSNA) for intraoperative detection of lymph node metastasis in breast cancer patients avoids second surgery and accelerates initiation of adjuvant therapy.

Klingler, S; Marchal, F; Rauch, P; Kenouchi, O; Chrétien, A S; Genin, P; Leroux, A; Merlin, J L

Klingler, S; Marchal, F; Rauch, P; Kenouchi, O; Chrétien, A S; Genin, P; Leroux, A; Merlin, J L.

Affiliation

Klingler S; Department of Biopathology, Institut de Cancérologie de Lorraine, Avenue de Bourgogne, CS 30519, 54519 Vandoeuvre les Nancy Cedex, France.

Ann Oncol ; 24(9): 2305-9, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23661291

Subject(s)

Breast Neoplasms/pathology; Breast Neoplasms/surgery; Intraoperative Care/methods; Lymph Nodes/pathology; Nucleic Acid Amplification Techniques; Axilla/diagnostic imaging; Axilla/pathology; Axilla/surgery; Chemotherapy, Adjuvant; Female; Humans; Immunohistochemistry; Intraoperative Period; Lymph Nodes/diagnostic imaging; Lymph Nodes/surgery; Lymphatic Metastasis; Middle Aged; RNA, Messenger/genetics; Radiography; Retrospective Studies; Sentinel Lymph Node Biopsy

Key words

CK19 mRNA; OSNA; PCR assay; breast cancer; intraoperative assay; sentinel lymph node

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Nucleic Acid Amplification Techniques / Intraoperative Care / Lymph Nodes Type of study: Diagnostic_studies / Observational_studies Limits: Female / Humans / Middle aged Language: En Journal: Ann Oncol Journal subject: NEOPLASIAS Year: 2013 Document type: Article Affiliation country: France

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