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Antitumoral effects of vasoactive intestinal peptide in human renal cell carcinoma xenografts in athymic nude mice.
Vacas, Eva; Arenas, M Isabel; Muñoz-Moreno, Laura; Bajo, Ana M; Sánchez-Chapado, Manuel; Prieto, Juan C; Carmena, María J.
Affiliation
  • Vacas E; Department of Systems Biology, Unit of Biochemistry and Molecular Biology, University of Alcalá, 28871 Alcalá de Henares, Spain.
Cancer Lett ; 336(1): 196-203, 2013 Aug 09.
Article in En | MEDLINE | ID: mdl-23664888
ABSTRACT
We studied antitumor effect of VIP in human renal cell carcinoma (RCC) (A498 cells xenografted in immunosuppressed mice). VIP-treated cells gave resulted in p53 upregulation and decreased nuclear ß-catenin translocation and NFκB expression, MMP-2 and MMP-9 activities, VEGF levels and CD-34 expression. VIP led to a more differentiated tubular organization in tumours and less metastatic areas. Thus, VIP inhibits growth of A498-cell tumours acting on the major issues involved in RCC progression such as cell proliferation, microenvironment remodelling, tumour invasion, angiogenesis and metastatic ability. These antitumoral effects of VIP offer new therapeutical possibilities in RCC treatment.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasoactive Intestinal Peptide / Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Kidney Neoplasms Limits: Animals / Humans / Male Language: En Journal: Cancer Lett Year: 2013 Document type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasoactive Intestinal Peptide / Carcinoma, Renal Cell / Gene Expression Regulation, Neoplastic / Kidney Neoplasms Limits: Animals / Humans / Male Language: En Journal: Cancer Lett Year: 2013 Document type: Article Affiliation country: Spain