Reinterpreting the action of ATP analogs on K(ATP) channels.

Ortiz, David; Gossack, Lindsay; Quast, Ulrich; Bryan, Joseph

Ortiz, David; Gossack, Lindsay; Quast, Ulrich; Bryan, Joseph.

Affiliation

Ortiz D; Pacific Northwest Diabetes Research Institute, Seattle, Washington 98122, USA.

J Biol Chem ; 288(26): 18894-902, 2013 Jun 28.

Article in En | MEDLINE | ID: mdl-23665564

Subject(s)

ATP-Binding Cassette Transporters/chemistry; Adenosine Triphosphate/analogs & derivatives; Adenylyl Imidodiphosphate/chemistry; Potassium Channels, Inwardly Rectifying/chemistry; Receptors, Drug/chemistry; Adenosine Triphosphate/chemistry; Adenosine Triphosphate/metabolism; Allosteric Site; Diabetes Mellitus/metabolism; Dimerization; Dose-Response Relationship, Drug; Humans; Hydrolysis; Inhibitory Concentration 50; Mutation; Pichia/metabolism; Protein Binding; Protein Conformation; Protein Interaction Domains and Motifs; Sulfonylurea Compounds/chemistry; Sulfonylurea Receptors

Key words

ABC Transporter; ABCC8; ATP Analogs; Allosteric Regulation; KATP Channels; Ligand-binding Protein; Neonatal Diabetes; Nucleoside Nucleotide Analogs; Potassium Channels; Sulfonylureas

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Drug / Adenosine Triphosphate / Adenylyl Imidodiphosphate / ATP-Binding Cassette Transporters / Potassium Channels, Inwardly Rectifying Limits: Humans Language: En Journal: J Biol Chem Year: 2013 Document type: Article Affiliation country: United States

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