Expressed prostatic secretion biomarkers improve stratification of NCCN active surveillance candidates: performance of secretion capacity and TMPRSS2:ERG models.

Whelan, Christopher; Kawachi, Mark; Smith, David D; Linehan, Jennifer; Babilonia, Gail; Mejia, Rosa; Wilson, Timothy; Smith, Steven S

Whelan, Christopher; Kawachi, Mark; Smith, David D; Linehan, Jennifer; Babilonia, Gail; Mejia, Rosa; Wilson, Timothy; Smith, Steven S.

Affiliation

Whelan C; Division of Urology, City of Hope, Duarte, California.
Kawachi M; Division of Urology, City of Hope, Duarte, California.
Smith DD; Division of Biostatistics, City of Hope, Duarte, California.
Linehan J; Division of Urology, City of Hope, Duarte, California.
Babilonia G; Division of Urology, City of Hope, Duarte, California.
Mejia R; Clinical Research Information Support, City of Hope, Duarte, California.
Wilson T; Division of Urology, City of Hope, Duarte, California.
Smith SS; Division of Urology, City of Hope, Duarte, California; Beckman Research Institute, City of Hope, Duarte, California. Electronic address: ssmith@coh.org.

J Urol ; 191(1): 220-6, 2014 Jan.

Article in En | MEDLINE | ID: mdl-23669563

Subject(s)

Biomarkers, Tumor/biosynthesis; Prostate/metabolism; Prostatic Neoplasms/metabolism; Antigens, Neoplasm/biosynthesis; Humans; Male; Middle Aged; Neoplasm Staging; Oncogene Proteins, Fusion/biosynthesis; Practice Guidelines as Topic; Prostate-Specific Antigen/biosynthesis; Prostatectomy; Prostatic Neoplasms/pathology; Prostatic Neoplasms/therapy; RNA, Messenger; Risk Assessment; Risk Factors; Thioredoxin Reductase 1/biosynthesis; Watchful Waiting

Key words

AS; DRE; ECE; EPS; PCA3; PCR; PCa; PSA; TMPRSS2:ERG; TXNRD1; active surveillance; bodily secretions; digital rectal examination; expressed prostatic secretion; extracapsular extension; neoplasm staging; polymerase chain reaction; prostate; prostate cancer; prostate cancer antigen 3 (nonprotein coding); prostate specific antigen; prostatic neoplasms; qPCR; quantitative PCR; risk; thioredoxin reductase 1; transmembrane protease, serine 2 gene fusion with v-ets erythroblastosis virus E26 oncogene like (avian) gene

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prostate / Prostatic Neoplasms / Biomarkers, Tumor Type of study: Etiology_studies / Guideline / Prognostic_studies / Risk_factors_studies / Screening_studies Limits: Humans / Male / Middle aged Language: En Journal: J Urol Year: 2014 Document type: Article

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