Nanoscale imaging reveals laterally expanding antimicrobial pores in lipid bilayers.

Rakowska, Paulina D; Jiang, Haibo; Ray, Santanu; Pyne, Alice; Lamarre, Baptiste; Carr, Matthew; Judge, Peter J; Ravi, Jascindra; Gerling, Ulla I M; Koksch, Beate; Martyna, Glenn J; Hoogenboom, Bart W; Watts, Anthony; Crain, Jason; Grovenor, Chris R M; Ryadnov, Maxim G

Rakowska, Paulina D; Jiang, Haibo; Ray, Santanu; Pyne, Alice; Lamarre, Baptiste; Carr, Matthew; Judge, Peter J; Ravi, Jascindra; Gerling, Ulla I M; Koksch, Beate; Martyna, Glenn J; Hoogenboom, Bart W; Watts, Anthony; Crain, Jason; Grovenor, Chris R M; Ryadnov, Maxim G.

Affiliation

Rakowska PD; National Physical Laboratory, Teddington TW11 0LW, United Kingdom.

Proc Natl Acad Sci U S A ; 110(22): 8918-23, 2013 May 28.

Article in En | MEDLINE | ID: mdl-23671080

Subject(s)

Antimicrobial Cationic Peptides/metabolism; Lipid Bilayers/chemistry; Nanotechnology/methods; Phospholipids/metabolism; Amino Acid Sequence; Antimicrobial Cationic Peptides/chemistry; Antimicrobial Cationic Peptides/genetics; Chromatography, High Pressure Liquid; Circular Dichroism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microscopy, Atomic Force; Molecular Dynamics Simulation; Molecular Sequence Data; Phospholipids/chemistry; Protein Engineering; Spectrometry, Mass, Secondary Ion

Key words

antibiotics; de novo protein design; innate host defense; nanometrology; nanoscopy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phospholipids / Antimicrobial Cationic Peptides / Nanotechnology / Lipid Bilayers Language: En Journal: Proc Natl Acad Sci U S A Year: 2013 Document type: Article Affiliation country: United kingdom

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