Variants of SLC6A4 in depression risk following severe TBI.
Brain Inj
; 27(6): 696-706, 2013 Jun.
Article
in En
| MEDLINE
| ID: mdl-23672445
ABSTRACT
BACKGROUND:
Post-traumatic depression (PTD) may be a result of several factors like secondary injury chemical cascades as well as psycho-social factors following traumatic brain injury (TBI). While the role of serotonin in the pathology and treatment of idiopathic major depression may be somewhat controversial, it is unclear what role serotonin may play in PTD following a TBI.OBJECTIVE:
To assess serotonergic function and genetic risk for PTD development over 1 year following TBI. RESEARCHDESIGN:
Examination of variation in the serotonin transporter gene [SLC6A4 (5-HTTLPR, rs25331, and a variable number of tandem repeats variant in Intron 2)] in 109 subjects with moderate-severe injury. Depression was assessed using the Patient Health Questionnaire (PHQ-9) at 6 and/or 12 months post-injury. MAIN OUTCOMES ANDRESULTS:
At 6 months post-injury, subjects with a history of pre-morbid mood disorders and 5-HTTLPR L-homozygotes were at greater risk for PTD. Contrary to major depression, subjects without pre-morbid mood disorders (n = 80) and S-carriers were 2.803-times less likely to be depressed compared to L-homozygotes. At 12 months post-injury, LG-carriers were also less likely to experience PTD. Temporal analysis also showed 5-HTTLPR associations in PTD development across recovery.CONCLUSIONS:
This study suggests a unique injury- and temporally-specific interaction between TBI and genetic risk for depression.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Injuries
/
Depression
/
Serotonin Plasma Membrane Transport Proteins
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
Language:
En
Journal:
Brain Inj
Journal subject:
CEREBRO
Year:
2013
Document type:
Article
Affiliation country:
United States