Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer.

Clem, Brian F; O'Neal, Julie; Tapolsky, Gilles; Clem, Amy L; Imbert-Fernandez, Yoannis; Kerr, Daniel A; Klarer, Alden C; Redman, Rebecca; Miller, Donald M; Trent, John O; Telang, Sucheta; Chesney, Jason

Clem, Brian F; O'Neal, Julie; Tapolsky, Gilles; Clem, Amy L; Imbert-Fernandez, Yoannis; Kerr, Daniel A; Klarer, Alden C; Redman, Rebecca; Miller, Donald M; Trent, John O; Telang, Sucheta; Chesney, Jason.

Affiliation

Clem BF; Division of Medical Oncology and Hematology, Department of Medicine, Louisville, KY, USA.

Mol Cancer Ther ; 12(8): 1461-70, 2013 Aug.

Article in En | MEDLINE | ID: mdl-23674815

Subject(s)

Antineoplastic Agents/pharmacology; Enzyme Inhibitors/pharmacology; Neoplasms/metabolism; Phosphofructokinase-2/antagonists & inhibitors; Animals; Antineoplastic Agents/chemistry; Apoptosis/drug effects; Cell Line, Tumor; Cell Survival/drug effects; Disease Models, Animal; Drug Screening Assays, Antitumor; Enzyme Inhibitors/chemistry; Female; Glucose/metabolism; Humans; Jurkat Cells; Mice; Models, Molecular; Molecular Conformation; Molecular Targeted Therapy; Neoplasms/drug therapy; Neoplasms/pathology; Phosphofructokinase-2/chemistry; Phosphofructokinase-2/metabolism; Protein Binding; Small Molecule Libraries; Tumor Burden/drug effects; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphofructokinase-2 / Enzyme Inhibitors / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2013 Document type: Article Affiliation country: United States Country of publication: United States

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