A novel aurora-A inhibitor, BPR1K0609S1, sensitizes colorectal tumor cells to 5-fluorofracil (5-FU) treatment.

Shionome, Yoshimi; Lin, Wen-Hsing; Shiao, Hui-Yi; Hsieh, Hsing-Pang; Hsu, John Tsu-An; Ouchi, Toru

Shionome, Yoshimi; Lin, Wen-Hsing; Shiao, Hui-Yi; Hsieh, Hsing-Pang; Hsu, John Tsu-An; Ouchi, Toru.

Affiliation

Shionome Y; Department of Medicine, NUHS, Pritzker School of Medicine, The University of Chicago, Evanston, USA.

Int J Biol Sci ; 9(4): 403-11, 2013.

Article in En | MEDLINE | ID: mdl-23678290

Subject(s)

Enzyme Inhibitors/pharmacology; Fluorouracil/pharmacology; Protein Serine-Threonine Kinases/metabolism; Animals; Aurora Kinase A; Aurora Kinases; Colorectal Neoplasms/drug therapy; Enzyme Inhibitors/therapeutic use; Female; Fluorouracil/therapeutic use; HCT116 Cells; Humans; Mice; Mice, Nude; Protein Serine-Threonine Kinases/antagonists & inhibitors

Key words

Aurora-A; apoptosis; cell cycle; kinase inhibitors; mice xenograft

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Enzyme Inhibitors / Fluorouracil Limits: Animals / Female / Humans Language: En Journal: Int J Biol Sci Journal subject: BIOLOGIA Year: 2013 Document type: Article Affiliation country: United States

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