Systemic ceramide accumulation leads to severe and varied pathological consequences.

Alayoubi, Abdulfatah M; Wang, James C M; Au, Bryan C Y; Carpentier, Stéphane; Garcia, Virginie; Dworski, Shaalee; El-Ghamrasni, Samah; Kirouac, Kevin N; Exertier, Mathilde J; Xiong, Zi Jian; Privé, Gilbert G; Simonaro, Calogera M; Casas, Josefina; Fabrias, Gemma; Schuchman, Edward H; Turner, Patricia V; Hakem, Razqallah; Levade, Thierry; Medin, Jeffrey A

Alayoubi, Abdulfatah M; Wang, James C M; Au, Bryan C Y; Carpentier, Stéphane; Garcia, Virginie; Dworski, Shaalee; El-Ghamrasni, Samah; Kirouac, Kevin N; Exertier, Mathilde J; Xiong, Zi Jian; Privé, Gilbert G; Simonaro, Calogera M; Casas, Josefina; Fabrias, Gemma; Schuchman, Edward H; Turner, Patricia V; Hakem, Razqallah; Levade, Thierry; Medin, Jeffrey A.

Affiliation

Alayoubi AM; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

EMBO Mol Med ; 5(6): 827-42, 2013 Jun.

Article in En | MEDLINE | ID: mdl-23681708

Subject(s)

Ceramides/metabolism; Farber Lipogranulomatosis/pathology; Acid Ceramidase/genetics; Acid Ceramidase/metabolism; Animals; Cells, Cultured; Chemokine CCL2/metabolism; Disease Models, Animal; Embryonic Stem Cells/cytology; Embryonic Stem Cells/metabolism; Farber Lipogranulomatosis/genetics; Farber Lipogranulomatosis/metabolism; Female; Gene Knock-In Techniques; Genetic Vectors/genetics; Genetic Vectors/metabolism; Homozygote; Humans; Lentivirus/genetics; Macrophages/immunology; Macrophages/physiology; Mice; Mutation; Phenotype

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ceramides / Farber Lipogranulomatosis Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: EMBO Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2013 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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