Voluntary movements as a possible non-reflexive pain assay.
Mol Pain
; 9: 25, 2013 May 20.
Article
in En
| MEDLINE
| ID: mdl-23688027
ABSTRACT
BACKGROUND:
The quantification of pain intensity in vivo is essential for identifying the mechanisms of various types of pain or for evaluating the effects of different analgesics. A variety of behavioral tests for pain measurement have been devised, but many are limited because animals are physically restricted, which affects pain sensation. In this study, pain assessment was attempted with minimal physical restriction, and voluntary movements of unrestrained animals were used to evaluate the intensities of various types of pain.RESULTS:
The number of times animals reared or total distances traveled was measured using a motion-tracking device and found to be markedly reduced in carrageenan-induced inflammatory, acetic acid-induced visceral, and streptozotocin-induced neuropathic pain tests. These two voluntary movement parameters were found to be highly correlated with paw withdrawal latency from irradiating heat. In addition, these parameters were markedly reversed by morphine and by non-steroidal anti-inflammatory drugs in inflammatory pain models. These parameters were also useful to detect hypoalgesia in TRPV1â»/â» mice.CONCLUSIONS:
These results suggest that parameters of voluntary movement, such as, number of rearing and total distance moved, are effective indicators of pain intensity for many types of pain and that they can be used to evaluate degree of pain perception.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain Measurement
/
Motor Activity
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Mol Pain
Journal subject:
BIOLOGIA MOLECULAR
/
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2013
Document type:
Article