Hyperactive transforming growth factor-ß1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model.

Rhodes, Steven D; Wu, Xiaohua; He, Yongzheng; Chen, Shi; Yang, Hao; Staser, Karl W; Wang, Jiapeng; Zhang, Ping; Jiang, Chang; Yokota, Hiroki; Dong, Ruizhi; Peng, Xianghong; Yang, Xianlin; Murthy, Sreemala; Azhar, Mohamad; Mohammad, Khalid S; Xu, Mingjiang; Guise, Theresa A; Yang, Feng-Chun

Rhodes, Steven D; Wu, Xiaohua; He, Yongzheng; Chen, Shi; Yang, Hao; Staser, Karl W; Wang, Jiapeng; Zhang, Ping; Jiang, Chang; Yokota, Hiroki; Dong, Ruizhi; Peng, Xianghong; Yang, Xianlin; Murthy, Sreemala; Azhar, Mohamad; Mohammad, Khalid S; Xu, Mingjiang; Guise, Theresa A; Yang, Feng-Chun.

Affiliation

Rhodes SD; Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

J Bone Miner Res ; 28(12): 2476-89, 2013 Dec.

Article in En | MEDLINE | ID: mdl-23703870

Subject(s)

Bone and Bones/abnormalities; Bone and Bones/metabolism; Neurofibromatosis 1/metabolism; Neurofibromatosis 1/pathology; Signal Transduction; Transforming Growth Factor beta1/metabolism; Animals; Bone and Bones/pathology; Cell Differentiation; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Disease Models, Animal; Gene Dosage; Haploinsufficiency; Humans; Integrases/metabolism; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/metabolism; Mesenchymal Stem Cells/metabolism; Mice; Mice, Transgenic; Models, Biological; Neurofibromin 1/deficiency; Neurofibromin 1/genetics; Osteoblasts/metabolism; Osteoblasts/pathology; Protein Serine-Threonine Kinases/metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/metabolism; Smad Proteins/metabolism; ras Proteins/metabolism

Key words

FRACTURE NONUNION; NEUROFIBROMATOSIS TYPE 1; OSTEOPOROSIS; SMAD; TGF-ß; TRANSFORMING GROWTH FACTOR-BETA

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone and Bones / Signal Transduction / Neurofibromatosis 1 / Transforming Growth Factor beta1 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Bone Miner Res Journal subject: METABOLISMO / ORTOPEDIA Year: 2013 Document type: Article Affiliation country: United States

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