The histone deacetylase inhibitor vorinostat prevents TNF&#945;-induced necroptosis by regulating multiple signaling pathways.

Wang, Di; Zhao, Ming; Chen, Guozhu; Cheng, Xiang; Han, Xiaoxi; Lin, Song; Zhang, Xuhui; Yu, Xiaodan

The histone deacetylase inhibitor vorinostat prevents TNFα-induced necroptosis by regulating multiple signaling pathways.

Wang, Di; Zhao, Ming; Chen, Guozhu; Cheng, Xiang; Han, Xiaoxi; Lin, Song; Zhang, Xuhui; Yu, Xiaodan.

Affiliation

Wang D; Department of Stress Medicine, Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, #27 Taiping Road, Beijing, 100850, China.
Zhao M; Department of Stress Medicine, Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, #27 Taiping Road, Beijing, 100850, China.
Chen G; Department of Stress Medicine, Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, #27 Taiping Road, Beijing, 100850, China.
Cheng X; Department of Stress Medicine, Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, #27 Taiping Road, Beijing, 100850, China.
Han X; Department of Biochemistry, China Medical University, Shenyang, China.
Lin S; Department of Stress Medicine, Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, #27 Taiping Road, Beijing, 100850, China.
Zhang X; Department of Stress Medicine, Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, #27 Taiping Road, Beijing, 100850, China.
Yu X; Department of Stress Medicine, Beijing Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, #27 Taiping Road, Beijing, 100850, China. yuxd@bmi.ac.cn.

Apoptosis ; 18(11): 1348-1362, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23708756

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Histone Deacetylase Inhibitors/pharmacology; Hydroxamic Acids/pharmacology; Necrosis/prevention & control; Neuroprotective Agents/pharmacology; Tumor Necrosis Factor-alpha/pharmacology; Animals; Autophagy/drug effects; CASP8 and FADD-Like Apoptosis Regulating Protein/agonists; CASP8 and FADD-Like Apoptosis Regulating Protein/genetics; CASP8 and FADD-Like Apoptosis Regulating Protein/metabolism; Cell Line, Tumor; Fibroblasts/drug effects; Fibroblasts/metabolism; Fibroblasts/pathology; Gene Expression Regulation; MAP Kinase Kinase 4/antagonists & inhibitors; MAP Kinase Kinase 4/genetics; MAP Kinase Kinase 4/metabolism; Mice; NF-kappa B/agonists; NF-kappa B/genetics; NF-kappa B/metabolism; Oncogene Protein v-akt/antagonists & inhibitors; Oncogene Protein v-akt/genetics; Oncogene Protein v-akt/metabolism; Signal Transduction; TOR Serine-Threonine Kinases/antagonists & inhibitors; TOR Serine-Threonine Kinases/genetics; TOR Serine-Threonine Kinases/metabolism; Vorinostat; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Inflammatory Agents, Non-Steroidal / Tumor Necrosis Factor-alpha / Neuroprotective Agents / Histone Deacetylase Inhibitors / Hydroxamic Acids / Necrosis Limits: Animals Language: En Journal: Apoptosis Year: 2013 Document type: Article Affiliation country: China Country of publication: Netherlands

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