Inhibition of BMP activity protects epithelial barrier function in lung injury.

Helbing, Thomas; Herold, Eva-Maria; Hornstein, Alexandra; Wintrich, Stefanie; Heinke, Jennifer; Grundmann, Sebastian; Patterson, Cam; Bode, Christoph; Moser, Martin

Helbing, Thomas; Herold, Eva-Maria; Hornstein, Alexandra; Wintrich, Stefanie; Heinke, Jennifer; Grundmann, Sebastian; Patterson, Cam; Bode, Christoph; Moser, Martin.

Affiliation

Helbing T; Cardiology and Angiology I, Heart Centre, Freiburg University, Freiburg, Germany.

J Pathol ; 231(1): 105-16, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23716395

Subject(s)

Bone Morphogenetic Protein 2/antagonists & inhibitors; Carrier Proteins/physiology; Epithelial Cells/metabolism; Lung Injury/metabolism; Respiratory Mucosa/physiology; Animals; Bleomycin/toxicity; Blood-Air Barrier; Bone Morphogenetic Protein 2/physiology; Cadherins/metabolism; Cell Line; Cell Membrane Permeability; Epithelial Cells/pathology; Humans; Lung Injury/chemically induced; Lung Injury/pathology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Pyrazoles/pharmacology; Pyrimidines/pharmacology; Signal Transduction/drug effects; Smad Proteins, Receptor-Regulated/metabolism; Up-Regulation

Key words

BMPER; bone morphogenetic protein; epithelial permeability; lung injury

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carrier Proteins / Respiratory Mucosa / Epithelial Cells / Lung Injury / Bone Morphogenetic Protein 2 Limits: Animals / Humans Language: En Journal: J Pathol Year: 2013 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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