Drug Discovery/standards; Drug-Related Side Effects and Adverse Reactions/metabolism; Pharmaceutical Preparations/standards; Animals; Drug Discovery/methods; Drug Discovery/trends; Drug Evaluation, Preclinical/methods; Drug Evaluation, Preclinical/standards; Drug Evaluation, Preclinical/trends; Drug Interactions/physiology; Drug-Related Side Effects and Adverse Reactions/prevention & control; Humans; Pharmaceutical Preparations/metabolism

ADR; AKI; ALP; ALT; AP; AST; Adverse Drug Reaction; BP; BUN; CLU; CNS; CVS; Cardiovascular; Cardiovascular System; Central Nervous System; Central nervous system; ECG; EEG; EMA; Electrocardiogram; European Medicines Agency; FDA; FOB; Food and Drug Administration; Functional Observation Battery; GFR; GGT; GI; GST; Gastrointestinal; Glomerular Filtration Rate; HR; ICH; International Conference on Harmonisation; KIM-1; LDH; N-acetyl-ß-d-glucosaminidase; NCE; NGAL; NMR; Neutrophil gelatinase-associated lipocalin; New Chemical Entity; Nuclear Magnetic Resonance; PBPK; PEB; RPA-1; Respiratory; Risk; SP; Safety Pharmacology; Safety pharmacology; TFF3; VQM; Ventilation (V)/perfusion (Q) mismatch (M); action potential; acute kidney injury; alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; blood pressure; blood urea nitrogen; clusterin; electroencephalography; glutathione S transferase; hERG; hESC; heart rate; human Ether-a-go-go related gene; human embryonic stem cells; kidney injury molecule-1; lactate dehydrogenase; miR; microRNA; photoelectric beam interruption technique; physiologically based pharmacokinetics; renal papillary antigen-1; trefoil factor 3; ß-NAG; γ-glutamyl transferase