Levels of pesticides and their metabolites in Wistar rat amniotic fluids and maternal urine upon gestational exposure.
Int J Environ Res Public Health
; 10(6): 2271-81, 2013 Jun 04.
Article
in En
| MEDLINE
| ID: mdl-23736656
ABSTRACT
Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pesticides
/
Prenatal Exposure Delayed Effects
/
Maternal Exposure
/
Amniotic Fluid
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Int J Environ Res Public Health
Year:
2013
Document type:
Article
Affiliation country:
Denmark
Country of publication:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND