Delayed anti-CD3 therapy results in depletion of alloreactive T cells and the dominance of Foxp3+ CD4+ graft infiltrating cells.

Goto, R; You, S; Zaitsu, M; Chatenoud, L; Wood, K J

Goto, R; You, S; Zaitsu, M; Chatenoud, L; Wood, K J.

Affiliation

Goto R; Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.

Am J Transplant ; 13(7): 1655-64, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23750800

Subject(s)

Antibodies, Monoclonal, Humanized/therapeutic use; CD3 Complex/drug effects; CD4-Positive T-Lymphocytes/immunology; Forkhead Transcription Factors/immunology; Graft Rejection/prevention & control; Graft Survival/drug effects; Heart Transplantation/immunology; Repressor Proteins/immunology; Animals; CD3 Complex/immunology; CD4-Positive T-Lymphocytes/drug effects; CD4-Positive T-Lymphocytes/pathology; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunospot Assay; Female; Flow Cytometry; Follow-Up Studies; Forkhead Transcription Factors/drug effects; Graft Rejection/immunology; Graft Rejection/pathology; Graft Survival/immunology; Heart Transplantation/pathology; Immunohistochemistry; Immunosuppression Therapy/methods; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Repressor Proteins/drug effects; Time Factors; Transplantation, Homologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / CD4-Positive T-Lymphocytes / Heart Transplantation / CD3 Complex / Forkhead Transcription Factors / Antibodies, Monoclonal, Humanized / Graft Rejection / Graft Survival Type of study: Guideline / Observational_studies / Prognostic_studies Limits: Animals Language: En Journal: Am J Transplant Journal subject: TRANSPLANTE Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United States

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