Omacetaxine mepesuccinate for patients with accelerated phase chronic myeloid leukemia with resistance or intolerance to two or more tyrosine kinase inhibitors.

Nicolini, Franck E; Khoury, H Jean; Akard, Luke; Rea, Delphine; Kantarjian, Hagop; Baccarani, Michele; Leonoudakis, Janis; Craig, Adam; Benichou, Annie-Claude; Cortes, Jorge

Nicolini, Franck E; Khoury, H Jean; Akard, Luke; Rea, Delphine; Kantarjian, Hagop; Baccarani, Michele; Leonoudakis, Janis; Craig, Adam; Benichou, Annie-Claude; Cortes, Jorge.

Haematologica ; 98(7): e78-9, 2013 Jul.

Article in En | MEDLINE | ID: mdl-23753022

Subject(s)

Antineoplastic Agents, Phytogenic/therapeutic use; Drug Resistance, Neoplasm/drug effects; Harringtonines/therapeutic use; Leukemia, Myeloid, Accelerated Phase/drug therapy; Protein Kinase Inhibitors/therapeutic use; Protein-Tyrosine Kinases/antagonists & inhibitors; Antineoplastic Agents, Phytogenic/pharmacology; Drug Resistance, Neoplasm/physiology; Follow-Up Studies; Harringtonines/pharmacology; Homoharringtonine; Humans; Leukemia, Myeloid, Accelerated Phase/enzymology; Leukemia, Myeloid, Accelerated Phase/mortality; Protein Kinase Inhibitors/pharmacology; Protein-Tyrosine Kinases/metabolism; Survival Rate/trends

Key words

advanced chronic myeloid leukemia; dasatinib; homoharringtonine; imatinib; nilotinib; omacetaxine; tyrosine kinase inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein-Tyrosine Kinases / Leukemia, Myeloid, Accelerated Phase / Drug Resistance, Neoplasm / Protein Kinase Inhibitors / Harringtonines / Antineoplastic Agents, Phytogenic Type of study: Observational_studies / Prognostic_studies Limits: Humans Language: En Journal: Haematologica Year: 2013 Document type: Article

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