Is an alternative drug delivery system needed for docetaxel? The role of controlling epimerization in formulations and beyond.

Manjappa, Arehalli S; Goel, Peeyush N; Vekataraju, Makam P; Rajesh, Kesarla S; Makwana, Kinjal; Ukawala, Mukesh; Nikam, Yuvraj; Gude, Rajiv P; Murthy, Rayasa S Ramachandra

Manjappa, Arehalli S; Goel, Peeyush N; Vekataraju, Makam P; Rajesh, Kesarla S; Makwana, Kinjal; Ukawala, Mukesh; Nikam, Yuvraj; Gude, Rajiv P; Murthy, Rayasa S Ramachandra.

Affiliation

Manjappa AS; TIFAC Centre of Relevance & Excellence in New Drug Delivery Systems, G.H. Patel Pharmacy Building, Pharmacy Department, The Maharaja Sayajirao University of Baroda, Donor's Plaza Fatehgunj, Vadodara, 390002, Gujarat, India.

Pharm Res ; 30(10): 2675-93, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23756759

Subject(s)

Antineoplastic Agents/administration & dosage; Drug Carriers/chemistry; Melanoma, Experimental/drug therapy; Polyethylene Glycols/chemistry; Taxoids/administration & dosage; Animals; Antineoplastic Agents/adverse effects; Antineoplastic Agents/chemistry; Antineoplastic Agents/therapeutic use; Cell Line, Tumor; Cell Survival/drug effects; Chemistry, Pharmaceutical; Docetaxel; Female; Humans; Liposomes; Melanoma, Experimental/pathology; Mice; Mice, Inbred C57BL; Molecular Structure; Solubility; Stereoisomerism; Surface Properties; Taxoids/adverse effects; Taxoids/chemistry; Taxoids/therapeutic use

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Melanoma, Experimental / Drug Carriers / Taxoids / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Pharm Res Year: 2013 Document type: Article Affiliation country: India Country of publication: United States

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