Targeted mutations in a highly conserved motif of the nsp1ß protein impair the interferon antagonizing activity of porcine reproductive and respiratory syndrome virus.

Li, Yanhua; Zhu, Longchao; Lawson, Steven R; Fang, Ying

Li, Yanhua; Zhu, Longchao; Lawson, Steven R; Fang, Ying.

Affiliation

Li Y; Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA.
Zhu L; Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA.
Lawson SR; Department of Veterinary and Biomedical Sciences, South Dakota State University, Brookings, SD 57007, USA.
Fang Y; Department of Biology/Microbiology, South Dakota State University, Brookings, SD 57007, USA.

J Gen Virol ; 94(Pt 9): 1972-1983, 2013 Sep.

Article in En | MEDLINE | ID: mdl-23761406

Subject(s)

Cysteine Proteases/metabolism; Host-Pathogen Interactions; Interferons/antagonists & inhibitors; Porcine respiratory and reproductive syndrome virus/immunology; Viral Nonstructural Proteins/metabolism; Amino Acid Sequence; Amino Acid Substitution; Animals; Cell Line; Cysteine Proteases/genetics; DNA Mutational Analysis; Humans; Immune Evasion; Interferons/metabolism; Macrophages/virology; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutant Proteins/genetics; Mutant Proteins/metabolism; Porcine respiratory and reproductive syndrome virus/genetics; Porcine respiratory and reproductive syndrome virus/growth & development; Reverse Genetics; Viral Nonstructural Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interferons / Viral Nonstructural Proteins / Porcine respiratory and reproductive syndrome virus / Host-Pathogen Interactions / Cysteine Proteases Limits: Animals / Humans Language: En Journal: J Gen Virol Year: 2013 Document type: Article Affiliation country: United States

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