Accurately identifying low-allelic fraction variants in single samples with next-generation sequencing: applications in tumor subclone resolution.

Stead, Lucy F; Sutton, Kate M; Taylor, Graham R; Quirke, Philip; Rabbitts, Pamela

Stead, Lucy F; Sutton, Kate M; Taylor, Graham R; Quirke, Philip; Rabbitts, Pamela.

Affiliation

Stead LF; Leeds Institute of Cancer and Pathology, St James's University Hospital, University of Leeds, Leeds, West Yorkshire, LS9 7TF, England.

Hum Mutat ; 34(10): 1432-8, 2013 Oct.

Article in En | MEDLINE | ID: mdl-23766071

Subject(s)

Alleles; Computational Biology/methods; High-Throughput Nucleotide Sequencing; Base Composition; Chromosome Mapping; Clone Cells; Gene Frequency; Genetic Testing/methods; Humans; Mutation; Neoplasms/diagnosis; Neoplasms/genetics; Polymorphism, Single Nucleotide; Reproducibility of Results

Key words

allelic frequency; mutation; next-generation sequencing; subclone; variant

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Computational Biology / Alleles / High-Throughput Nucleotide Sequencing Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Hum Mutat Journal subject: GENETICA MEDICA Year: 2013 Document type: Article Affiliation country: United kingdom Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google