Bupropion/pharmacology; CA3 Region, Hippocampal/pathology; CA3 Region, Hippocampal/physiopathology; Neurons/cytology; Neurons/drug effects; Seizures/pathology; Seizures/physiopathology; Animals; Anticonvulsants/pharmacology; Anticonvulsants/therapeutic use; Bupropion/therapeutic use; CA3 Region, Hippocampal/drug effects; CA3 Region, Hippocampal/metabolism; Cell Death/drug effects; Dose-Response Relationship, Drug; Epilepsy, Temporal Lobe/drug therapy; Epilepsy, Temporal Lobe/pathology; Epilepsy, Temporal Lobe/physiopathology; Kainic Acid; Male; Microglia/drug effects; Microglia/physiology; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/metabolism; Nerve Degeneration/chemically induced; Nerve Degeneration/drug therapy; Nerve Degeneration/pathology; Neurons/pathology; Phosphorylation/drug effects; Proto-Oncogene Proteins c-fos/metabolism; Rats; Seizures/chemically induced; Seizures/drug therapy; Seizures/metabolism

Bupropion; ERK1/2; Excitotoxicity; Hippocampus; JNK; KA; Kainic acid; MAPKs; Neuroprotection; PBS; Seizure; TBS; Tris-buffered saline; c-Jun N-terminal kinase; extracellular signal-regulated kinase; i.p.; intraperitoneal; kainic acid; mitogen-activated protein kinases; phosphate-buffered saline