Ribavirin is not effective against Crimean-Congo hemorrhagic fever: observations from the Turkish experience.
Int J Infect Dis
; 17(10): e799-801, 2013 Oct.
Article
in En
| MEDLINE
| ID: mdl-23773242
ABSTRACT
Crimean-Congo hemorrhagic fever (CCHF) is a viral infection associated with a high mortality rate. Ribavirin is the only drug used in the treatment of this disease. Studies investigating the effectiveness of ribavirin in CCHF have been retrospective and to date have included only a small number of cases. In recent years, due to climate changes, the number of cases of CCHF in Turkey has increased, and experience in the treatment of CCHF has improved. Several studies have evaluated the efficacy of ribavirin in Turkey, including one randomized controlled trial and two studies with a large number of cases. In these studies, ribavirin therapy was not shown to decrease mortality rates; the mortality rate was 2-9% in patients treated with ribavirin and 5.6-11% in those who were not treated with this drug. These findings suggest that patients with CCHF should be followed with supportive care only until randomized controlled trials with larger groups have been conducted.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Ribavirin
/
Hemorrhagic Fever, Crimean
Type of study:
Clinical_trials
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Int J Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2013
Document type:
Article
Affiliation country:
Turkey