Metabolism and disposition of [(14)C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application.

Mathews, James M; Watson, Scott L; Patel, Purvi R; Black, Sherry R; Hong, Yan; Levine, Keith E; Ross, Glenn; Germolec, Dori R; Thakur, Sheetal A; Waidyanatha, Suramya

Mathews, James M; Watson, Scott L; Patel, Purvi R; Black, Sherry R; Hong, Yan; Levine, Keith E; Ross, Glenn; Germolec, Dori R; Thakur, Sheetal A; Waidyanatha, Suramya.

Affiliation

Mathews JM; RTI International, Drug Metabolism and Pharmacokinetics , Research Triangle Park , USA , and.

Xenobiotica ; 44(1): 36-47, 2014 Jan.

Article in En | MEDLINE | ID: mdl-23786350

Subject(s)

Boranes/administration & dosage; Boranes/metabolism; Dimethylamines/administration & dosage; Dimethylamines/metabolism; Administration, Cutaneous; Administration, Intravenous; Animals; Boranes/pharmacokinetics; Carbon Radioisotopes/administration & dosage; Carbon Radioisotopes/pharmacokinetics; Carbon Radioisotopes/urine; Dimethylamines/pharmacokinetics; Dimethylnitrosamine/blood; Dimethylnitrosamine/urine; Feces/chemistry; Humans; Male; Rats; Rats, Sprague-Dawley; Sodium Nitrite/administration & dosage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boranes / Dimethylamines Limits: Animals / Humans / Male Language: En Journal: Xenobiotica Year: 2014 Document type: Article Country of publication: United kingdom

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