Investigating the feasibility of temperature-controlled accelerated drug release testing for an intravaginal ring.

Externbrink, Anna; Clark, Meredith R; Friend, David R; Klein, Sandra

Externbrink, Anna; Clark, Meredith R; Friend, David R; Klein, Sandra.

Affiliation

Externbrink A; Department of Pharmacy, University of Greifswald, Greifswald, Germany.

Eur J Pharm Biopharm ; 85(3 Pt B): 966-73, 2013 Nov.

Article in En | MEDLINE | ID: mdl-23791685

Subject(s)

Chemistry, Pharmaceutical/methods; Desogestrel/analogs & derivatives; Drug Delivery Systems; Ethinyl Estradiol/chemistry; Temperature; Administration, Intravaginal; Calorimetry, Differential Scanning; Delayed-Action Preparations; Desogestrel/chemistry; Diffusion; Drug Combinations; Female; Humans; Kinetics; Permeability; Polymers/chemistry; Quality Control; Solubility; Vagina/drug effects

Key words

Diffusion-controlled drug release; Extended release delivery systems; Nuvaring®; Quality control; Reciprocating holder; USP apparatus 7; Vaginal delivery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Temperature / Chemistry, Pharmaceutical / Drug Delivery Systems / Desogestrel / Ethinyl Estradiol Limits: Female / Humans Language: En Journal: Eur J Pharm Biopharm Journal subject: FARMACIA / FARMACOLOGIA Year: 2013 Document type: Article Affiliation country: Germany Country of publication: Netherlands

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