Caspase-14 overexpression in hairless mice is not involved in utricle formation.
Exp Dermatol
; 22(7): 484-6, 2013 Jul.
Article
in En
| MEDLINE
| ID: mdl-23800061
ABSTRACT
Loss of functional hairless (HR) transcriptional repressor leads to utricle formation and congenital hair loss both in mice and men. Studies in mice have shown that this is preceded by overexpression of caspase-14 at the infundibulum in the hair follicle before conversion to utricle occurs. In this report, we show that HR regulates caspase-14 expression dependent on its interaction with histone deacetylases, implicating chromatin remodelling in the transcriptional regulation of caspase-14. However, crossing hairless mutant mice with caspase-14-deficient mice revealed that caspase-14 overexpression is not the cause of utricle formation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Enzymologic
/
Saccule and Utricle
/
Hair Follicle
/
Caspases
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Histone Deacetylases
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Dermatol
Journal subject:
DERMATOLOGIA
Year:
2013
Document type:
Article