Potent inhibition of DOT1L as treatment of MLL-fusion leukemia.

Daigle, Scott R; Olhava, Edward J; Therkelsen, Carly A; Basavapathruni, Aravind; Jin, Lei; Boriack-Sjodin, P Ann; Allain, Christina J; Klaus, Christine R; Raimondi, Alejandra; Scott, Margaret Porter; Waters, Nigel J; Chesworth, Richard; Moyer, Mikel P; Copeland, Robert A; Richon, Victoria M; Pollock, Roy M

Daigle, Scott R; Olhava, Edward J; Therkelsen, Carly A; Basavapathruni, Aravind; Jin, Lei; Boriack-Sjodin, P Ann; Allain, Christina J; Klaus, Christine R; Raimondi, Alejandra; Scott, Margaret Porter; Waters, Nigel J; Chesworth, Richard; Moyer, Mikel P; Copeland, Robert A; Richon, Victoria M; Pollock, Roy M.

Affiliation

Daigle SR; Epizyme, Inc., 400 Technology Square, Cambridge, MA 02139, USA.

Blood ; 122(6): 1017-25, 2013 Aug 08.

Article in En | MEDLINE | ID: mdl-23801631

Subject(s)

Antineoplastic Agents/pharmacology; Benzimidazoles/pharmacology; Histone-Lysine N-Methyltransferase/antagonists & inhibitors; Leukemia/genetics; Leukemia/therapy; Methyltransferases/antagonists & inhibitors; Myeloid-Lymphoid Leukemia Protein/genetics; Animals; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Dose-Response Relationship, Drug; Female; Histone Methyltransferases; Histones/metabolism; Humans; Neoplasm Transplantation; Protein Conformation; Rats; Rats, Nude

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Leukemia / Histone-Lysine N-Methyltransferase / Myeloid-Lymphoid Leukemia Protein / Methyltransferases / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Blood Year: 2013 Document type: Article Affiliation country: United States

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