Topical efficacy of dimercapto-chelating agents against lewisite-induced skin lesions in SKH-1 hairless mice.

Mouret, Stéphane; Wartelle, Julien; Emorine, Sandy; Bertoni, Marine; Nguon, Nina; Cléry-Barraud, Cécile; Dorandeu, Frédéric; Boudry, Isabelle

Mouret, Stéphane; Wartelle, Julien; Emorine, Sandy; Bertoni, Marine; Nguon, Nina; Cléry-Barraud, Cécile; Dorandeu, Frédéric; Boudry, Isabelle.

Affiliation

Mouret S; Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, Centre de Recherches du Service de Santé des Armées, 24 avenue Maquis du Grésivaudan, 38700 La Tronche, France. Electronic address: stephane.mouret@irba.fr.

Toxicol Appl Pharmacol ; 272(2): 291-8, 2013 Oct 15.

Article in En | MEDLINE | ID: mdl-23806213

Subject(s)

Arsenic Poisoning/prevention & control; Arsenicals/administration & dosage; Chelating Agents/therapeutic use; Dermatitis/prevention & control; Dimercaprol/therapeutic use; Succimer/therapeutic use; Administration, Topical; Animals; Arsenic Poisoning/etiology; Arsenic Poisoning/pathology; Chelating Agents/administration & dosage; Chelating Agents/adverse effects; Dermatitis/etiology; Dermatitis/pathology; Dimercaprol/administration & dosage; Dimercaprol/adverse effects; Injections, Subcutaneous; Male; Mice; Mice, Hairless; Succimer/administration & dosage; Succimer/adverse effects; Volatilization

Key words

British anti-lewisite (BAL); Dimercaptosuccinic acid (DMSA); Lewisite; Skin lesion; Topical application; Treatment

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arsenicals / Chelating Agents / Succimer / Arsenic Poisoning / Dermatitis / Dimercaprol Type of study: Etiology_studies Limits: Animals Language: En Journal: Toxicol Appl Pharmacol Year: 2013 Document type: Article

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