Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78.

Martin, S; Lamb, H K; Brady, C; Lefkove, B; Bonner, M Y; Thompson, P; Lovat, P E; Arbiser, J L; Hawkins, A R; Redfern, C P F

Martin, S; Lamb, H K; Brady, C; Lefkove, B; Bonner, M Y; Thompson, P; Lovat, P E; Arbiser, J L; Hawkins, A R; Redfern, C P F.

Affiliation

Martin S; Newcastle Cancer Centre at the Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, UK.

Br J Cancer ; 109(2): 433-43, 2013 Jul 23.

Article in En | MEDLINE | ID: mdl-23807168

Subject(s)

Antineoplastic Agents, Phytogenic/therapeutic use; Apoptosis/drug effects; Biphenyl Compounds/therapeutic use; Catechin/analogs & derivatives; Heat-Shock Proteins/metabolism; Lignans/therapeutic use; Neoplasms/drug therapy; Antineoplastic Agents, Phytogenic/metabolism; Biphenyl Compounds/metabolism; Catechin/metabolism; Catechin/therapeutic use; Cell Line, Tumor; Cell Survival/drug effects; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress/drug effects; Heat-Shock Proteins/antagonists & inhibitors; Humans; Lignans/metabolism; Molecular Targeted Therapy; Molecular Weight; Neoplasms/pathology; Protein Binding/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biphenyl Compounds / Catechin / Apoptosis / Lignans / Heat-Shock Proteins / Neoplasms / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Br J Cancer Year: 2013 Document type: Article Affiliation country: United kingdom

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