Facile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers.

Agelis, George; Kelaidonis, Konstantinos; Resvani, Amalia; Kalavrizioti, Dimitra; Androutsou, Maria-Eleni; Plotas, Panagiotis; Vlahakos, Demetrios; Koukoulitsa, Catherine; Tselios, Theodore; Mavromoustakos, Thomas; Matsoukas, John

Agelis, George; Kelaidonis, Konstantinos; Resvani, Amalia; Kalavrizioti, Dimitra; Androutsou, Maria-Eleni; Plotas, Panagiotis; Vlahakos, Demetrios; Koukoulitsa, Catherine; Tselios, Theodore; Mavromoustakos, Thomas; Matsoukas, John.

Affiliation

Agelis G; Department of Chemistry, University of Patras, Patras 26500, Greece. aggelisgeorge@hotmail.com

Molecules ; 18(7): 7510-32, 2013 Jun 27.

Article in En | MEDLINE | ID: mdl-23807577

Subject(s)

Angiotensin II Type 1 Receptor Blockers/chemical synthesis; Angiotensin II Type 1 Receptor Blockers/pharmacology; Antihypertensive Agents/chemical synthesis; Antihypertensive Agents/pharmacology; Imidazoles/pharmacology; Angiotensin II Type 1 Receptor Blockers/chemistry; Antihypertensive Agents/chemistry; Drug Design; Humans; Imidazoles/chemical synthesis; Imidazoles/chemistry; Molecular Docking Simulation; Receptor, Angiotensin, Type 1/metabolism; Structure-Activity Relationship; Urocanic Acid/chemistry; Urocanic Acid/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Angiotensin II Type 1 Receptor Blockers / Imidazoles / Antihypertensive Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2013 Document type: Article Affiliation country: Greece Country of publication: Switzerland

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